abstract：:Dysmorphologic and anthropometric assessments were performed on 154 6-year-old children prenatally exposed to cocaine (PCE) and 131 high-risk controls (NCE) of similar race and social class. Adjusted mean height z scores demonstrated a dose-response with metahydroxybenzoylecgonine above a threshold of 100 ng/g of meco...

journal_title：Neurotoxicology and teratology

authors： Minnes S,Robin NH,Alt AA,Kirchner HL,Satayathum S,Salbert BA,Ellison L,Singer LT

更新日期：2006-01-01 00:00:00

abstract：:Methylmercury (MeHg), an environmental contaminant primarily found in fish and seafood, may pose long-term health risks to pregnant women and their developing children. The objective of this study was to determine whether co-consumption of nutritional supplements would alter the effects of MeHg on reproductive and dev...

journal_title：Neurotoxicology and teratology

authors： Beyrouty P,Chan HM

更新日期：2006-01-01 00:00:00

abstract：:The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameter...

journal_title：Neurotoxicology and teratology

authors： Feng L,Xiao H,He X,Li Z,Li F,Liu N,Chai Z,Zhao Y,Zhang Z

更新日期：2006-01-01 00:00:00

abstract：:Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l(-1) in drinking water, for 90 days) on electroencephalographic ...

journal_title：Neurotoxicology and teratology

authors： Lestaevel P,Bussy C,Paquet F,Dhieux B,Clarençon D,Houpert P,Gourmelon P

更新日期：2005-11-01 00:00:00

abstract：:While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, ...

journal_title：Neurotoxicology and teratology

authors： MacPhail RC,Jarema KA

更新日期：2005-09-01 00:00:00

abstract：:The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (n=8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas natu...

journal_title：Neurotoxicology and teratology

authors： Golub MS,Hogrefe CE,Germann SL,Tran TT,Beard JL,Crinella FM,Lonnerdal B

更新日期：2005-07-01 00:00:00

abstract：:In the literature on the effects of early exposure to neurotoxic agents on infant and child development, considerable attention has been devoted to two important issues--ascertainment of exposure and spurious correlation. In this paper, we review these research challenges and focus on three additional issues that, in ...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW

更新日期：2005-05-01 00:00:00

abstract：:Lead (Pb) is a well-known poison interfering with calcium homeostasis and dopaminergic pathway. We hypothesized that environmental Pb exposure can interact with prolactin (PRL) secretion, regulated by calcium and dopamine, during pregnancy and in fetus. The objective of this longitudinal study was to determine the rel...

journal_title：Neurotoxicology and teratology

authors： Takser L,Mergler D,Lafond J

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses str...

journal_title：Neurotoxicology and teratology

authors： Sood BG,Nordstrom Bailey B,Covington C,Sokol RJ,Ager J,Janisse J,Hannigan JH,Delaney-Black V

更新日期：2005-03-01 00:00:00

abstract：:Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...

journal_title：Neurotoxicology and teratology

authors： Wolansky MJ,Azcurra JM

更新日期：2005-03-01 00:00:00

abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...

journal_title：Neurotoxicology and teratology

authors： Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar A

更新日期：2005-01-01 00:00:00

abstract：:Zidovudine (AZT) is the main therapeutic agent against HIV vertical transmission and is routinely administered to seropositive pregnant women and their newborns. Toxicity after chronic administration as well as citogenetic effects following developmental AZT exposure has been reported. Furthermore, recent animal data ...

journal_title：Neurotoxicology and teratology

authors： Venerosi A,Valanzano A,Puopolo M,Calamandrei G

更新日期：2005-01-01 00:00:00

abstract：:Exposure to ethanol during development can lead to a constellation of congenital anomalies, resulting in prenatal and postnatal failure to thrive, central nervous system (CNS) deficits, and a number of patterning defects that lead to defects in the cardiovascular system, facial structures, and limbs. The cellular, bio...

journal_title：Neurotoxicology and teratology

authors： Carvan MJ 3rd,Loucks E,Weber DN,Williams FE

更新日期：2004-11-01 00:00:00

abstract：:1-beta-D-Arabinofuranosylcytosine (Ara-C), a cytidine analogue cytotoxic to proliferating cells, has a teratogenic effect in the brain of experimental animals and causes neural cell apoptosis in vitro and in vivo. In the present study, pregnant rats were injected with Ara-C on Day 13 of gestation and the fetal brain w...

journal_title：Neurotoxicology and teratology

authors： Yamauchi H,Katayama K,Ueno M,Uetsuka K,Nakayama H,Doi K

更新日期：2004-07-01 00:00:00

abstract：:Reversible protein phosphorylation is a central mechanism regulating many biological functions, and abnormal protein phosphorylation can have a devastating impact on cellular control mechanisms, including a contributing role in neurodegenerative processes. Hence, many promising novel drug development strategies involv...

journal_title：Neurotoxicology and teratology

authors： Amador FC,Henriques AG,da Cruz E Silva OA,da Cruz E Silva EF

更新日期：2004-05-01 00:00:00

abstract：:Measures of visual contrast sensitivity (VCS), rather than traditional measures of visual acuity using high-contrast stimuli, have been presented as better appraisals of visual dysfunction resulting from chemical exposures. The present study sought to determine if differences exist between two available measures of co...

journal_title：Neurotoxicology and teratology

authors： Hitchcock EM,Dick RB,Krieg EF

更新日期：2004-03-01 00:00:00

abstract：:In spite of significant efforts, the neurobehavioral deficits in infants born from cocaine-abusing mothers have not been clearly defined. In the present study, we examined the presence of these abnormalities in a rhesus monkey model of prenatal cocaine exposure using a nonhuman primate adaptation of the Neonatal Behav...

journal_title：Neurotoxicology and teratology

authors： He N,Bai J,Champoux M,Suomi SJ,Lidow MS

更新日期：2004-01-01 00:00:00

abstract：:A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...

journal_title：Neurotoxicology and teratology

authors： Samsam TE,Gadrinab LG,Bushnell PJ

更新日期：2004-01-01 00:00:00

abstract：:The prevalence and magnitude of effect of individual risk markers for specific developmental disorders vary widely across diagnostic category. The four study cohorts for this project were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SI...

journal_title：Neurotoxicology and teratology

authors： Klug MG,Burd L,Kerbeshian J,Benz B,Martsolf JT

更新日期：2003-11-01 00:00:00

abstract：:In this study we used a rat model of graded perinatal asphyxia to study the long-term consequences of this manipulation on rat maternal behavior at adulthood. Rats were delivered by cesarean (C) section and the pups, still in the uterus horns, were placed into a water bath at 37 degrees C for periods of 0 (controls) o...

journal_title：Neurotoxicology and teratology

authors： Cirulli F,Bonsignore LT,Venerosi A,Valanzano A,Chiarotti F,Alleva E

更新日期：2003-09-01 00:00:00

abstract：:Cognitive performance was examined in 145 thirteen- to sixteen-year-old adolescents for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects were from a low-risk, predominantly middle-class sample participating in an ongoing, longitudinal study. The assessment battery included tests of...

journal_title：Neurotoxicology and teratology

authors： Fried PA,Watkinson B,Gray R

更新日期：2003-07-01 00:00:00

abstract：:Pregnant C57BL/6 mice were chronically treated with 0, 4, 6, or 8 ppm of methylmercury chloride (MeHg) in drinking water during fetal and early postnatal development. Four behavioral functions were analyzed in female and male offspring between the age of 6 and 12 weeks: motor coordination learning on the rotarod; trai...

journal_title：Neurotoxicology and teratology

authors： Goulet S,Doré FY,Mirault ME

更新日期：2003-05-01 00:00:00

abstract：:AZT (azidothymidine, zidovudine, ZDV) has become the standard medication to prevent the transmission of the human immunodeficiency virus from mother to fetus. The present study was designed to assess the acoustic startle response (ASR) in adult rats that had been perinatally exposed to AZT. Each litter was randomly as...

journal_title：Neurotoxicology and teratology

authors： Melnick SM,Weedon J,Dow-Edwards DL

更新日期：2002-11-01 00:00:00

abstract：:The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) leads to the hypothesis that Parkinson's disease (PD) is maybe initiated or precipitated by environmental or endogenous toxins by the mechanism similar to that of MPTP in genetically-predisposed individuals. Endogenous analogs of MPTP, such as beta-c...

journal_title：Neurotoxicology and teratology

authors： Matsubara K,Aoyama K,Suno M,Awaya T

更新日期：2002-09-01 00:00:00

abstract：:Diabetes is known to be one of the risk factors for dementia; however, neuropathic changes in the brain of patients with the disease have not been completely revealed. So in the present study, we investigated the brain function of rats with diabetes induced by streptozotocin (STZ), one of the most commonly used animal...

journal_title：Neurotoxicology and teratology

authors： Nitta A,Murai R,Suzuki N,Ito H,Nomoto H,Katoh G,Furukawa Y,Furukawa S

更新日期：2002-09-01 00:00:00

abstract：:Male Fischer 344 rats received either tap water or water containing 250 ppm lead for 90 days prior to training in either Pavlovian fear conditioning or consummatory contrast, an aversive reward reduction paradigm. In Experiment 1, lead-exposed and -unexposed rats were trained in operant chambers over a 6-min session. ...

journal_title：Neurotoxicology and teratology

authors： Salinas JA,Huff NC

更新日期：2002-07-01 00:00:00

abstract：:Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW

更新日期：2002-05-01 00:00:00

abstract：:To assess teratogenic effects of cocaine exposure and maternal psychological distress on birth outcomes, we conducted a longitudinal prospective study of 415 infants (218 cocaine-exposed--CE, 197 nonexposed--NE). Drug exposure was determined through a combination of maternal self-report, urine, and meconium screens. M...

journal_title：Neurotoxicology and teratology

authors： Singer LT,Salvator A,Arendt R,Minnes S,Farkas K,Kliegman R

更新日期：2002-03-01 00:00:00

abstract：:The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behav...

journal_title：Neurotoxicology and teratology

authors： Temple JG,Miller DB,Barthalmus GT

更新日期：2002-03-01 00:00:00

abstract：:Estrogen modulates baseline and amphetamine-stimulated dopamine (DA) release in the adult female rat striatum. The isoflavone found in soybeans, genistein, is a phytoestrogen and may have comparable effects on striatal DA levels. Similarly, the industrial intermediate and potential endocrine disrupter, para-nonylpheno...

journal_title：Neurotoxicology and teratology

authors： Ferguson SA,Flynn KM,Delclos KB,Newbold RR,Gough BJ

更新日期：2002-01-01 00:00:00

abstract：:Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

journal_title：Neurotoxicology and teratology

authors： Oshiro WM,Krantz QT,Bushnell PJ

更新日期：2001-11-01 00:00:00

abstract：:We examined the relationship between acquired color vision loss and exposure to toluene and total hydrocarbons among 125 male workers. Seventy-two toluene-exposed printers were compared with 34 workers from the same photogravure plant with ambient background exposure, and with 19 workers from a bookbinding plant locat...

journal_title：Neurotoxicology and teratology

authors： Campagna D,Stengel B,Mergler D,Limasset JC,Diebold F,Michard D,Huel G

更新日期：2001-09-01 00:00:00

abstract：:The effects of maternal urinary tract infection (UTI) or endotoxin exposure on fetal outcome in rats were investigated. Prior to conception, dams of the UTI group were water-deprived and anesthetized. The urinary tract was then catheterized and injected with 0.2 of 1 x 10(9) Escherichia coli. The endotoxin group was i...

journal_title：Neurotoxicology and teratology

authors： Cronise K,Kelly SJ

更新日期：2001-07-01 00:00:00

abstract：:Using a timed-breeding protocol, one group of female rhesus monkeys was implanted subcutaneously with osmotic minipumps containing 0.3 mg/kg/h cocaine (N=18) or saline (N=18) from day 24 postconception through gestation. Another group received cocaine (N=12) or saline (N=8) from conception through day 42 of gestation....

journal_title：Neurotoxicology and teratology

authors： Howell LL,Schama KF,Ellis JE,Grimley PJ,Kitchens AJ,Byrd LD

更新日期：2001-03-01 00:00:00

abstract：:Bromantan (N-[2-adamantil]-N-[para-bromphenyl]amine) is an "actoprotective" drug widely used in Russia as a muscle performance-enhancing agent for sportsmen and as an immunostimulator in medicine. Experiments were conducted to determine whether this compound has adverse effects on the reproduction and development of o...

journal_title：Neurotoxicology and teratology

authors： Iezhitsa IN,Spasov AA,Bugaeva LI

更新日期：2001-03-01 00:00:00

abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

journal_title：Neurotoxicology and teratology

authors： Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

更新日期：2000-11-01 00:00:00

abstract：:Previous studies have shown that maternal doses of 1 microg/kg or less of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in late gestation can demasculinize and feminize reproductive behavior in male rats. However, it was not known whether coplanar polychlorinated biphenyls (PCBs) had similar effects, or whether non-repro...

journal_title：Neurotoxicology and teratology

authors： Amin S,Moore RW,Peterson RE,Schantz SL

更新日期：2000-09-01 00:00:00

abstract：:Visual thresholds for luminance increments were obtained behaviorally and electrophysiologically from rats exposed to a polychlorinated biphenyl (PCB) during development. Male Long-Evans rats exposed to 0, 0.25, or 1.0 microg/kg/day of 3,3',4,4', 5-pentachlorobiphenyl (PCB 126) through gestation and weaning were train...

journal_title：Neurotoxicology and teratology

authors： Geller AM,Bushnell PJ,Rice DC

更新日期：2000-07-01 00:00:00

abstract：:The present study was aimed at investigating the long-term effects of prenatal exposure to lamivudine (3TC), an antiretroviral drug used in clinical practice alone or in combination with zidovudine (AZT) to prevent mother-to-child transmission of the HIV virus. Pregnant CD-1 mice were given per os twice daily either 3...

journal_title：Neurotoxicology and teratology

authors： Calamandrei G,Venerosi A,Branchi I,Valanzano A,Alleva E

更新日期：2000-05-01 00:00:00

abstract：:This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

journal_title：Neurotoxicology and teratology

authors： Al Deeb S,Al Moutaery K,Khan HA,Tariq M

更新日期：2000-03-01 00:00:00